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KMID : 0370220030470060417
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Yakhak Hoeji
2003 Volume.47 No. 6 p.417 ~ p.421
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Synthesis of 2’-Methyl and 4’-Hydroxy Branched Novel Carbocyclic Nucleosides
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홍준희/Hong JH
고옥현/Ko OH
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Abstract
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This paper describes a synthetic route to novel 2’-emthyl and 4’-hydroxy carbocyclic nucleosides. The methyl group was successfully installed by carbonyl addition reaction of isopropenyl magnesium bromide followed by ring-closing metathesis and the hydroxy group was directly introduced from carbohydrate chiral template "D-lactose".
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